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During the almost twenty years afterthose clinical trials utilizing adoptive transfer of in vitro expanded TIL during IL-2 therapycellular immunologist where not only able to recognize the existence of Tregs, but also haddeveloped detailed knowledge about T cell immunobiology. Historically,this was often the in vivo chromosome aberration assay, butmore recently the in vivo micronucleus assay (see oECD TG474) has gained in popularity primarily because of its ease ofuse. For example, the Western assumption that dis-closure and emotional catharsis lead to healing may not have a global application. In children, the situation of measure-ment becomes even more complex because of limitations in the use of self-reportat younger ages. Furthermore, many controlled trials do not con-fi rm findings from observational studies
Furthermore, many controlled trials do not con-fi rm findings from observational studies. van der Meer IM, Bots ML, Hofman A, del Sol AI, vander Kuip DA, Witteman JC
van der Meer IM, Bots ML, Hofman A, del Sol AI, vander Kuip DA, Witteman JC.